Which progressive neurological disorder primarily causes motor dysfunction?

Severe Parkinson's Disease is primarily known for causing motor dysfunction due to its impact on the basal ganglia and the dopaminergic system. The hallmark symptoms of Parkinson's include tremors, rigidity, bradykinesia (slowness of movement), and postural instability. These symptoms arise from the degeneration of neurons in the substantia nigra, a critical area of the brain involved in the control of movement.

While other progressive neurological disorders can also result in motor issues, Parkinson's Disease is particularly recognized for the specific motor symptoms it produces as a result of its pathophysiology. Its progression leads to significant impairment in voluntary motor control, making it a primary concern in patients diagnosed with this condition.

Other options may cause motor dysfunction as well, but they typically have additional cognitive or systemic symptoms that play a significant role in the overall presentation of the disease. For example, Multiple Sclerosis can lead to motor function issues, but it often presents with a variety of neurological symptoms beyond just motor impairment. Amyotrophic Lateral Sclerosis does cause muscle weakness due to motor neuron degeneration, but it encompasses a wider symptom profile related to both upper and lower motor neuron involvement. Huntington's Disease is primarily characterized by involuntary movements (ch