Which antidepressant is known to cause sexual side effects?

Paroxetine is known to cause sexual side effects, making it a common choice in discussions about the impact of antidepressants on sexual function. Sexual side effects, such as decreased libido, erectile dysfunction, and difficulties with orgasm, are frequently reported with selective serotonin reuptake inhibitors (SSRIs), and paroxetine is particularly notorious for these effects.

This effect is likely due to its potent serotonin reuptake inhibition, which can influence sexual arousal and response pathways. Among SSRIs, paroxetine consistently shows a higher incidence of sexual side effects as compared to others in the same class. Although all SSRIs have the potential to cause such side effects, paroxetine's profile makes it an important consideration for clinicians when prescribing antidepressants, especially in patients concerned about sexual health.