What is the antibiotic of choice for treating syphilis?

Penicillin G is the antibiotic of choice for treating syphilis due to its effectiveness against Treponema pallidum, the bacterium that causes the disease. This medication has a long history of successful use in treating all stages of syphilis, including primary, secondary, and tertiary forms. The pharmacokinetics of Penicillin G allow for adequate levels to be attained in the body, which is crucial for eradicating the infection.

In addition to its effectiveness, Penicillin G is preferable due to its safety profile and established guidelines from health authorities, such as the Centers for Disease Control and Prevention (CDC), which specifically recommend it as the first-line treatment. This makes it a staple in the management of syphilis in various clinical settings, ensuring a high cure rate.

Alternative antibiotics like Amoxicillin, Ciprofloxacin, and Azithromycin do not provide the same level of efficacy against syphilis, particularly in all stages of the disease. While some studies have investigated the use of Azithromycin as an alternative, resistance issues and inconsistent efficacy have limited its recommendation. Therefore, Penicillin G remains the gold standard in syphilis treatment.