What is a hallmark of Multiple Myeloma as it relates to bone health?

Multiple Myeloma is a type of cancer that affects plasma cells in the bone marrow, leading to various complications, particularly in bone health. A hallmark sign of Multiple Myeloma is bone pain and fractures due to the disease's destructive effect on bone tissue. The malignant plasma cells produce substances that lead to bone resorption, which results in the weakening of bones and makes them more susceptible to fractures. Patients often report localized bone pain in areas such as the back or ribs, and the occurrence of pathologic fractures is common. This significant impact on bone health is what makes bone pain and fractures a key clinical indication of Multiple Myeloma.

In contrast, the other options do not align with the characteristic complications of the disease. For instance, bone density typically decreases, not increases, as a result of the disease. Calcium levels tend to be elevated due to bone breakdown, and hemoglobin levels are often low due to associated anemia rather than increased. Thus, the presence of bone pain and fractures serves as a critical identifying feature of Multiple Myeloma.