What is a common effect of endothelial dysfunction in relation to pregnancy?

Endothelial dysfunction is a significant factor that can lead to complications during pregnancy, with preeclampsia being one of the most common conditions associated with this dysfunction. Preeclampsia is characterized by hypertension and proteinuria, and it can have severe consequences for both the mother and the fetus.

During pregnancy, the endothelium (the layer of cells lining blood vessels) undergoes numerous adaptations to support the growing placenta and fetus. If endothelial dysfunction occurs, it can result in impaired vasodilation, increased vascular permeability, and an inflammatory response, which contribute to the development of high blood pressure and other related symptoms. This state impacts uterine, placental, and maternal blood flow, potentially leading to the development of preeclampsia.

This condition can escalate to more severe complications like HELLP syndrome, but preeclampsia itself directly resulting from endothelial dysfunction is a common manifestation. Other options, like increased appetite and weight gain, while potentially relevant during pregnancy, do not specifically relate to the pathological processes involved in endothelial dysfunction as closely as preeclampsia does.