For a 17-year-old female suspected of polycystic ovary syndrome, what diagnostic tests should be ordered in addition to testosterone?

When evaluating a 17-year-old female suspected of polycystic ovary syndrome (PCOS), it is important to assess various hormones to determine the underlying endocrine status, which can help in diagnosing the condition. The correct answer includes ordering FSH (follicle-stimulating hormone), LH (luteinizing hormone), and TSH (thyroid-stimulating hormone), as this combination provides valuable insights into the reproductive and thyroid function of the patient.

FSH and LH are crucial for assessing the functioning of the hypothalamic-pituitary-gonadal axis. In PCOS, there is typically an imbalance between LH and FSH, often presenting with elevated LH levels and normal or low FSH levels. This hormonal profile is characteristic of the condition and helps differentiate PCOS from other causes of hyperandrogenism.

TSH is also important to evaluate because thyroid dysfunction can present similarly to PCOS. It is essential to rule out hypothyroidism or hyperthyroidism as contributing factors to the symptoms exhibited by the patient, such as menstrual irregularities and potential hyperandrogenism.

While measuring estradiol and progesterone can provide information regarding ovarian function, they are not as central in the initial diagnostic workup